Paraoxonase-1 and Early-Life Environmental Exposures
نویسندگان
چکیده
منابع مشابه
Epigenetic gene regulation: early environmental exposures.
Environmental epigenetics Traditional research on the combined effects of genetics and the environment investigates how individuals differ in susceptibility to disease and how susceptibility changes over time. The majority of these gene–environment interaction studies focus on genetic sequence variants, including single nucleotide polymorphisms (SNPs), which influence toxicant uptake, metabolis...
متن کاملAdolescent epigenetic profiles and environmental exposures from early life through peri-adolescence
Epigenetic perturbations induced by environmental exposures at susceptible lifestages contribute to disease development. Even so, the influence of early life and ongoing exposures on the adolescent epigenome is rarely examined. We examined the association of exposure biomarkers for lead (Pb), bisphenol A (BPA), and nine phthalates metabolites with blood leukocyte DNA methylation at LINE-1 repet...
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Exploring possible epigenetic mediation of early-life environmental exposures on adiposity and obesity development Rebecca C Richmond, Nicholas J Timpson and Thorkild IA Sørensen* MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark...
متن کاملPredicting Later-Life Outcomes of Early-Life Exposures
BACKGROUND In utero exposure of the fetus to a stressor can lead to disease in later life. Epigenetic mechanisms are likely mediators of later-life expression of early-life events. OBJECTIVES We examined the current state of understanding of later-life diseases resulting from early-life exposures in order to identify in utero and postnatal indicators of later-life diseases, develop an agenda ...
متن کاملPredicting Later-Life Outcomes of Early-Life Exposures
Why do some people struggle with obesity or develop such diseases as cancer or diabetes? One might speculate that interactions between people’s genes and environmental factors must be responsible, but which environmental factors play a role? And how and when do their crucial interactions with genes occur? By altering complex developmental processes, human experiences and exposures in the womb a...
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ژورنال
عنوان ژورنال: Annals of Global Health
سال: 2016
ISSN: 2214-9996
DOI: 10.1016/j.aogh.2016.01.009